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Etodolac, like other nsaids, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increased toxicity.

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Spironolactone reduced digoxin clearance, increased risk of digoxin toxicity.

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These interactions are related to the fact that digoxin-zori affects contractility and excitability of the heart in a manner similar to that of calcium.

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Cholestyramine moderate cholestyramine has been shown to significantly interfere with the absorption of digoxin.

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Drugs used to treat heart-rhythm problems, such as amiodarone cordarone, pacerone , dronedarone multaq and digoxin digox, lanoxin .

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Renal excretion of digoxin is proportional to glomerular filtration rate and is largely independent of urine flow.

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